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Lophotrochozoa get into the game: the nodal pathway and left/right asymmetry in bilateria

机译:恶性疟原虫进入游戏:节点中的淋巴结途径和左/右不对称

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摘要

Animals as diverse as humans, flies, crabs, and snails show overall bilateral symmetry, but each species has specific structures and organs that display left/right asymmetry, and the presence of these asymmetries is vital to the organism. Here, we review recent results showing that part of the molecular pathway that sets left/right asymmetry in vertebrates is also conserved in snails, suggesting that left/right asymmetry was present in the common ancestor of all bilaterians. More specifically, we can now predict that the signaling molecule Nodal and the transcription factor Pitx were expressed on the right side of the bilaterian ancestor. These results also allow us to understand how the direction of shell coiling (chirality) is regulated in snails and provides interesting insights into the possible inversion of the dorsoventral axis in the lineage leading to chordates.
机译:动物,如人类,苍蝇,螃蟹和蜗牛,都表现出整体的双侧对称性,但是每种物种都有特定的结构和器官,表现出左右不对称性,而这些不对称性的存在对有机体至关重要。在这里,我们回顾了最近的结果,结果显示在蜗牛中还保留了在脊椎动物中设置左/右不对称性的分子途径的一部分,这表明在所有双语者的共同祖先中都存在左/右不对称性。更具体地说,我们现在可以预测,信号分子Nodal和转录因子Pitx在双侧祖先的右侧表达。这些结果还使我们能够了解蜗牛中壳卷曲(手性)的方向是如何调节的,并提供了有趣的见解,以了解在导致脊索动物的血统中背腹轴的可能倒置。

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